Microarray analysis of erythromycin resistance determinants
نویسندگان
چکیده
منابع مشابه
Macrolide resistance determinants in erythromycin-resistant Streptococcus pneumoniae in Turkey.
To determine the major molecular mechanisms of macrolide resistance among Streptococcus pneumoniae isolates in Turkey, we examined a total of 151 isolates collected from different regions of Turkey. Overall, 40 (26.4%) isolates were resistant to erythromycin. The most common mechanism (38/40) was target site modification due to erm (B) genes. Only two isolates harbored the mef (A)/(E) efflux ge...
متن کاملMacrolide resistance and erythromycin resistance determinants among Belgian Streptococcus pyogenes and Streptococcus pneumoniae isolates.
Resistance of streptococci to macrolide antibiotics is caused by target-site modification or drug efflux. The phenotypic expression of target-site modification can be inducible or constitutive. The prevalence of the three phenotypes among Belgian erythromycin-resistant Group A streptococci (GAS) and Streptococcus pneumoniae isolates was surveyed, their MICs for seven antibiotics were determined...
متن کاملAlteration in Transformability of Diplococcus Pneumoniae after the Acquisition of Genetic Determinants Inducing Resistance to Erythromycin.
Sirotnak, Francis M. (Sloan-Kettering Institute for Cancer Research, New York, N.Y.), Ramona B. Lunt, and Dorris J. Hutchison. Alteration in transformability of Diplococcus pneumoniae after the acquisition of genetic determinants inducing resistance to erythromycin. J. Bacteriol. 86:735-739. 1963.-The genetic alteration of a highly transformable (competent) recipient strain of Diplococcus pneum...
متن کاملErythromycin resistance in Borrelia burgdorferi.
Susceptibility testing of laboratory strains and clinical isolates of Borrelia burgdorferi indicates that resistance to erythromycin is present in them. Evaluation of the MICs, minimal bactericidal concentrations, and kinetics of bacterial killing of erythromycin suggests that this resistance is increased by preexposure to the antibiotic, is dependent on inoculum size, and may be the result of ...
متن کاملErythromycin resistance by ribosome modification.
Erythromycin inhibits protein synthesis by its effect on ribosome function (14, 118, 119). The metabolic modifications that enable cells to cope with the inhibitory action of erythromycin fall under major headings that include (i) target site alteration, (ii) antibiotic modification, and (iii) altered antibiotic transport. This minireview concentrates on target site alteration, which for erythr...
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ژورنال
عنوان ژورنال: Journal of Applied Microbiology
سال: 2003
ISSN: 1364-5072,1365-2672
DOI: 10.1046/j.1365-2672.2003.02046.x